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    In the Tittha Sutta, some monks remarked to the Buddha that there are many followers of other teachings with differing opinions, who bicker
    According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product
    with one another on what is and is not the truth. The Buddha described the situation with a story... Once, a king gathered men blind from
    ; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

    Examples of combination products may in
    irth before an elephant. To some, he "showed" a tusk, and to others the trunk, body, foot, hind, tail and tuft. Next, he asked what they "s
    lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

    w". Those who touched the head said it was like a winnowing basket, while the tusk was like an iron rod, the trunk like a plow pole, the bo
    here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe
    y like a granary, the foot like a post, the hind like a mortar, the tail like a pestle, and the tuft like a broom. The blind men then argue
    d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

    Combination pro
    and fought over their "views" of what the elephant was really like. The Buddha remarked that those who are blind to the Dharma (the truth,
    ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc
    or the way to the truth) do not know what is beneficial or harmful - thus do they argue over it.

    To argue with animosity is harmful. It m
    easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi
    kes one blind to the truth to be seen with calm and clear introspection. The Buddha himself discusses the Dharma peacefully, even with the
    nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically
    uarrelsome. Arguments often arise over varied perspectives. Two blind men might even "see" the same part of an elephant differently. The vi
    and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ
    ws of the blind men were partially correct, not totally so. This means they were also subjectively (in other ways) and objectively
    ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi
    wrong. In truth, elephants have no parts made of baskets and such. Their descriptions were superficial, based on perceptions of previously
    ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

    Following aspects would a
    touched items. They did not even know how real baskets look like, much less elephants! Physical blindness in the parable represents spiritu
    dd to the challenges in developing combination products:

    Which markets to tap where the combination products can do fairly well?
    Which combination prod
    l blindness. There are many ways one can be blind, with none as blind as those who will not see. Our lack of complete insight into reality
    cts are meaningful and rational?
    Which therapeutic categories to select?
    Which Combinations can address unmet needs of the patients?
    Do combin
    eans we are still blind to some extent. But we can always learn to see better. This requires diligent spiritual cultivation.

    The parable s
    tions increase the patient compliance?
    What would be the developing cost?
    How to tackle the risks encountered during combination product developmen
    ems to hint that many might be preaching different parts of the same truth, while some mistaken individual parts to be complete. It is simp
    t?

    As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel
    istic to take sides without reflections on the possibility of being blind to one's own blindness. One might not be totally blind, but with
    ping new procedures for reviewing their safety, efficacy and quality.

    Professional from academic institutions, pharmaceutical industries, health care indust
    certain blindspots.

    In business and life in general, we usually get dogmatic to our own ideas and viewpoints too. It is crucial to main
    y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products
    ain an open-minded to rid ourselves of the blindness that most businessmen are afflicted with. But, at the same time, once we have realise
    .

    As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de
    the "truth" in business, when we have realised that it is futile to continue arguing about certain business actions or decisions, we shoul
    elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

    Companies that provide selfless information through particip
    take the bold step ahead.

    You may notice that the successful businessmen sometimes do not spend time on arguing but rather taking actions


    tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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