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At the beginning of the web era, users would go to directories to find sites relevant to their interests. In fact, Yahoo!

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

, the web's number one destination, started as a directory. Nowadays, most users rely on search engines, not directories,

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

to find what they're looking for.

When search engines started to become popular, they relied on web pages' 'keyword meta

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

tags' to determine the topic and relevance of the page (the keyword metatag is a section within a web page's HTML code wh

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

re webmasters can insert words that are relevant to the page's content). Webmasters discovered that by stuffing their met

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

a tags with popular search terms repeated hundreds of times, they could propel their pages to the top of the search resul

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

s.

Search engines caught up to the abuse and decided to ignore the meta tags and rely instead on web page copy. Webmaste

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

rs then started to overstuff their page copy with popular search terms, often writing them in the same color as the web p

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

ge's background, so that they could be detected by search engines while being invisible to users.

Again, search engines

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

discovered the trick and decided that the best way to rank a web page's content and its topical relevance was to rely on

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

nbound links from other pages. The rationale behind this is that it is much more difficult to influence other people to l

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

ink to you than it is to manipulate your own web page elements. In fact, inbound links are the foundation of Google's Pag

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

rank™ algorithm.

There are several ways to get inbound links, among them writing articles that include your bylines with

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

a link to your page, exchanging links, and listing your site in directories.

Listing your sites in good directories is

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

robably the best way to get quality links that are highly valued by the search engines. Since directories rely on human e

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

ditors who enforce strict criteria to list a site, and since directories organize the information in highly focused categ

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

ries, they are an invaluable resource for search engines to measure the quality and the relevance of a web page.

In summ

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

ary, directories are important not because they generate significant traffic (they don't), but because they are given gre

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

t importance by the search engines to qualify and rank web pages, and to determine their topical relevance.

You should d

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

efinitely list your site with quality directories if you want to increase your chances of success with the search engines

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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