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Spam increased by 13% in 2005, and average spam levels in 2006 will remain at 2005’s level of 85% of all email traffic – according to spam filtering specialist SoftScan. (http://w

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

ww.softscan.co.uk)

Imagine the above statistic of 85% is your inbox. You have been away for the weekend and upon your return, you decide to check your Inbox to see if you've got

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

ny important messages you need to deal with (and to see if your friends have sent you any funny pictures of course). Your Inbox total reads 100 unread messages. Wow, you sure are

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

popular lately! It's only been a couple of days.

You open your Inbox and are immediately downcast as you trawl through the mass of spam (unsolicited) emails. Out of 100 messages

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

nly 15 will be what we call 'real' mail. Of course this is assuming you don't have any spam filtering service, either with your ISP / Mailhost or on your email client.

The advent

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

of ISP's and the like using spam filters and automatic virus checkers has certainly made a huge impact on the amount we no longer receive in our inboxes, but these are not infall

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

ble. Quite often the people who send spam find ways to circumvent the filters, or legitimate mail ends up in the spam/bulk email folders and you have to wade through it all anyway

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

.

Ways in which to stop spam:

Use email filtering, on your own computer as well as your ISPs.
Only give out your email address to friends, rel

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

tives and trusted colleagues. Use web based email for anything else. Be aware though, that a lot of web based email services such as msn and yahoo are used by spammers and as such

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

some websites do not accept registrations from these.

If you send an email to all your friends, don't put them all in to the 'to' field, use Bcc.

Make sure your

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

email software is set to not show images and disable HTML mail, use plain text instead.

Don't forget to run anti-spyware programmes regularly.

If you join a webs

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

ite or forum, only use those who give you the option to hide your email address.

Don't click the opt out link in an email, if it is from a reputable site, go to the site

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

nd search for their opt out link that way. If it is spam, all it will do it verify your email address as valid.

Report spam to the senders ISP.

There is a wealth

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

of information on the internet on how to deal with unwanted emails. It is worth your while spending a little time to research.

How to deal with the stress of spam:
tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen
ng>

It is very annoying, time consuming and stressful having to deal with all that spam. It takes time out of your day where you could be doing something useful, or not. So how d
t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel
o you keep yourself from getting too stressed whilst wading through it all?

That is a question I can't answer, as we all respond to and deal with stress differently. I can howeve
ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust
tell you how I have managed to actually find time to laugh at the vast amounts of spam I receive.

After sending any spam that dared to invade my Inbox to the spam folder, I then
y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products
go into the spam folder to check for legitimate mail. Once that's done, I take a minute to look at the senders name on all the spam. These are automated random names, designed to
.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de
look as though they are from real addresses/people, but I find some of them humourous and look through to find the funniest. It only takes a couple of minutes, but laughing at it
elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip
takes the stress away from having it at all, and then I can get on with the rest of my time online relaxed. Don't let spam bother you, deal with it, laugh at it and then forget it

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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