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    The lingo of the web, Hypertext Markup Language more commonly referred to as HTML, has grown in many ways since its cr
    According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product
    eation. HTML has had to keep pace with the ever changing World Wide Web and as a result there are now several differe
    ; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

    Examples of combination products may in
    t versions of HTML.


    In The Beginning


    Hypertext Markup Language was originally created to share hypert
    lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

    xt online documentation, news, mail, hypermedia, etc. The first version of HTML was the backbone of what we now call t
    here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe
    e World Wide Web. Can you imagine the web without images? The first HTML version was not able to display graphics as
    d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

    Combination pro
    it didn’t support the image tag.


    In the beginning there was no standardization either which meant that different
    ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc
    browsers displayed web pages differently from each other. Even today you can see differences in web pages depending o
    easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi
    which browser you use, but the slight differences you see today are minute compared to the first version of HTML.
    nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

    As you can imagine the lack of standardization created many growing pains as the World Wide Web grew in size and acce
    and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ
    ptance. As a result HTML changed to keep up with the ever growing web. In an attempt to formalize HTML, version 2 wa
    ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi
    created and was the basis for web browsers. After several versions throughout the years, version 4.01 is the current
    ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

    Following aspects would a
    standard, widely used today.


    XHTML The successor to HTML


    The next generation of HTML is XHTML whic
    dd to the challenges in developing combination products:

    Which markets to tap where the combination products can do fairly well?
    Which combination prod
    is just a stricter HTML version. This stricter version of HTML was introduced as more and more people are using lapt
    cts are meaningful and rational?
    Which therapeutic categories to select?
    Which Combinations can address unmet needs of the patients?
    Do combin
    ops with wireless computing, mobile phones, PDA’s, etc.


    Since XHTML is strictly standardized, automated validato
    tions increase the patient compliance?
    What would be the developing cost?
    How to tackle the risks encountered during combination product developmen
    s can be used to find coding errors, unlike HTML which is often hard to test. XHTML should improve browser compatibil
    t?

    As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel
    ty and make web pages easier to maintain also.


    However change can be a long process as many older browsers can
    ping new procedures for reviewing their safety, efficacy and quality.

    Professional from academic institutions, pharmaceutical industries, health care indust
    nly render XHTML as HTML, as opposed to popular browsers that deliver XHTML correctly. The World Wide Web Consortium c
    y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products
    urrently recommends the use of XHMTL 1.0, XHMTL 1.1 and HTML 4.01.


    Just as the world is ever changing and evolvin
    .

    As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de
    you can be sure that the World Wide Web will follow suit. It’s evident that the progression from the first version o
    elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

    Companies that provide selfless information through particip
    HTML to the latest XHMTL is only a fraction of the change that web users and designers will witness in the future.

    tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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